1. Biomedical Photonics: A Revolution at the Interface of Science and Technology

Tuan Vo-Dinh 1-1

I. Photonics and Tissue Optics

2. Optical Properties of Tissue

Joel Mobky and Tuan Vo-Dinh. 2-1

3. Light-Tissue Interactions

Valery V. Tuchin. 3-1

4. Theoretical Models and Algorithms in Optical Diffusion Tomography

Stephen J. Norton and Tuan Vo-Dinh. 4-1

II. Photonic Devices

5. Laser Light in Biomedicine and the Life Sciences: From the Present to the Future

Vladilen S. Letokhov. 5-l

6. Basic Instrumentation in Photonics

Tuan Vo-Dinh. 6-l

7. Optical Fibers and Waveguides for Medical Applications

Israel Gannot and MosheBen-David. 7-l

8. Biological Imaging Spectroscopy Gregory Bearman and Richard Levenson. 8-1

III. Photonic Detection and Imaging Techniques

9. Lifetime-Based Imaging

Petr Herman, Hai-Jui Lin, and Joseph R. Lakowicz. 9-1

10. Confocal Microscopy

Tony Wilson. 10-l

11. Two-Photon Excitation Fluorescence Microscopy

Peter T. C. So, Chen Y. Dong and Barry R. Masters.11-1

12. Near-Field Imaging in Biological and Biomedical Applications

VolkerDeckert. 12-1

13. Optical Coherence Tomography Imaging

James G. Fujimoto and Mark E. Brezinski. 13-1

14. Speckle Correlometry

DmitryA. Zimnyakov and Valery V. Tuchin . l4-l

15. Laser Doppler Perfusion Monitoring and Imaging

Gert E. Nilsson, E. Goran Salerud, N. 0. Tomas Stromberg, andKarin Wardell. l5-l

16. Light Scatter Spectroscopy and Imaging of Cellular and Subcellular Events

Nada N. Boustany and Nitish V. Thakor. 16-1

17. Thermal Imaging for Biological and Medical Diagnostics

Jay P. Gore and Lisa X.Xu .17-1

IV. Biomedical Diagnostics I

18. Glucose Diagnostics

Gerard L. Cote and Roger ]. McNichols. 18-1

19. In Vitro Clinical Diagnostic Instrumentation

Gerald E. Cohn and Richard Domanik. 19-1

20. Biosensors for Medical Applications

Tuan Vo-Dinh and Leonardo Allain . 20-1

21. Functional Imaging with Diffusing Light

Arjun G. Yodh and David A. Boas. 21-1

22. Photon Migration Spectroscopy Frequency-Domain Techniques

Albert E. Cerussi and Bruce ]. Tromberg. 22-1

23. Atomic Spectrometry in Biological and Clinical Analysis

Andrew Taylor. 23-1

24. Capillary Electrophoresis Techniques in Biomedical Analysis

S. Douglass Gilman and Michael I. Sepaniak. 24-1

25. Flow Cytometry

Francis Mandy, Rudi Varro, and Diether Recktenwald. 25-1

26. X-Ray Diagnostic Techniques

Xizeng Wu, Abby E. Deans, and Hong Liu. 26-1

27. Optical Pumping and MRI of Hyperpolarized Spins

Xizeng Wu, Thomas Nishino,and Hong Liu . 27-l

V. Biomedical Diagnostics II: Optical Biopsy

28. Fluorescence Spectroscopy for Biomedical Diagnostics

Tuan Vo-Dinh and Brian M. Cullum . 28-1

29. Elastic-Scattering Spectroscopy and Diffuse Reflectance

Judith R. Mourant and Irving J. Bigio. 29-1

30. Raman Spectroscopy: From Benchtop to Bedside

Anita Mahadevan-Jansen. 30-l

31. Quantitative Characterization of Biological Tissue Using Optical Spectroscopy

Irene Georgakoudi, Jason T. Mote, Vadim Backman, George Angheloiu, Abigail S. Haka, Markus M?ller, Ramachandra Dasari, and Michael S. Feld. 31-1

32. Recent Developments in Fourier Transform Infrared (FTIR) Microspectroscopic Methods for Biomedical Analyses: From Single-Point Detection to Two-Dimensional Imaging

Rohit Bhargava and Ira W. Levin. 32-1

33. Near-Infrared Fluorescence Imaging and Spectroscopy in Random Media and Tissues

Eva M. Sevick-Muraca, Eddy Kuwana, Anuradha Godavarty, Jessica P. Houston, Alan B. Thompson, and Ranadhir Roy. 33-1

34. Optoacoustic Tomography

Alexander A. Oraevsky and Alexander A.Karabutov. 34-1

35. Ultrasonically Modulated Optical Imaging

Juliette Selb, Sandrine Leveque-Fort, Arnaud Dubois, Benoit C. Forget, Lionel Pottier, Francois Ramaz, and Claude Boccara. 35-1

VI Intervention and Treatment Techniques

36. Mechanistic Principles of Photodynamic Therapy

Barbara W. Henderson and Sandra 0. Gollnick . 36-1

37. Synthetic Strategies in Designing Porphyrin-Based Photosensitizers for Photodynamic Therapy

Ravindra K. Pandey. 37-1

38. Photodynamic Therapy (PDT) and Clinical Applications

Thomas J. Dougherty and Julia G. Levy. 38-1

39. Laser Tissue Welding

Karen M. McNally-Heintzelman and Ashley J. Welch. 39-1

40. Lasers in Dermatology

Kittisak Suthamjariya and R. RoxAnderson. 40-1

41. Lasers in Interventional Pulmonology

Anubhav N. Mathur and Praveen N. Mathur. 41-1

42. Lasers in Neurosurgery

Devin K. Binder, Meic H. Schmidt, Rose Du, and Mitchel S.Berger. 42-1

43. Lasers in Ophthalmology

Ezra Maguen, Thomas G. Chu, and David Boyer. 43-1

44 .Lasers in Otolaryngology

Lou Reinisch. 44-1

45. Lasers in Urology

John T. Leyland II, DetlefF. Albrecht, and Steven H. Selman . 45-1

46. Therapeutic Applications of Lasers in Gastroenterology

Masoud Panjehpour and BergeinF. Overholt. 46-1

47. Laser Treatment of Breast Tumors

Gavin M. Briggs, Andrew C. Lee, and Stephen G. Bown. 47-1

48. Low-Power Laser Therapy

Tiina I. Karu. 48-1

49. Image-Guided Surgery

Richard D. Bucholz and Keith A. Laycock. 49-1

50. Optical Methods for Caries Detection, Diagnosis, and Therapeutic Intervention

Daniel Fried. 50-1

VII. Advanced Biophotonics for Genomics, Proteomics, and Medicine

51. Biochips and Microarrays: Tools for the New Medicine

Tuan Vo-Dinh. 51-1

52. Array Technologies and Multiplex Genetic Analysis

Youxaing Wang, Carmen Virgos, Sharat Singh, Maureen T. Cronin, Stephen J. Williams, and Elaine S. Mansfield . 52-1

53. DNA Sequencing Using Fluorescence Detection

Steven A. Soper, Clyde V. Owens, Suzanne J. Lassiter, Yichuan Xu, and Emanuel Waddell. 53-1

54. Living-Cell Analysis Using Optical Methods

Pierre M. Viallet and Tuan Vo-Dinh. 54-l

55. Amplification Techniques for Optical Detection

Guy D. Griffin, M. Wendy Williams, Dimitra N. Stratis-Cullum, and Tuan Vo-Dinh. 55-1

56. Fluorescent Probes in Biomedical Applications

Darryl J. Bornhop and Kai Licha. 56-l

57. Novel Fluorescent Molecular Beacon DNA Probes for Biomolecular Recognition

Kemin Wang, Jun Li, Xiaohong Fang, Sheldon Schuster, Marie Vicens, Shannon Kelley, Hua Lou, Jianwei Jeffery Li, Terry Beck, Richard Hogrefe, and Weihong Tan . 57-1

58. Luminescent Quantum Dots as Advanced Biological Labels

Warren C. W. Chan and Shuming Nie. 58-1

59. PEBBLE Nanosensors for in Vitro Bioanalysis

Eric Monson, Murphy Brasuel, Martin A. Philbert, and Raoul Kopelman. 59-1

60. Nanosensors for Single-Cell Analyses

Brian M. Cullum and Tuan Vo-Dinh . 60-1

61. Advanced Photonics: Optical Trapping Techniques in Bioanalysis

Kenji Yasuda. 61-1

62. In Vivo Bioluminescence Imaging as a Tool for Drug Development

Christopher H. Contag and Pamela R. Contag. 62-1

63. Liposome-Based Systems for Biomedical Diagnostics and Therapy

Thuvan Nguyen, Gabriela Dumitrascu, Nitsa Rosenzweig, and Zeev Rosenzweig. 63-1

64. Surface-Enhanced Raman Scattering (SERS) for Biomedical Diagnostics

Tuan Vo-Dinh and David L. Stokes . 64-1

VIII Appendix

65. Spectroscopic Data of Biologically and Medically Relevant Species and Samples

Dimitra N. Stratis-Cullum, David L. Stokes, Brian M. Cullum, Joon-Myong Song, Paul M. Kasili, Ramesh Jagannathan, Joel Mobley, and Tuan Vo-Dinh . 65-1

Index.. .Index-l